Low Momentum Nucleon-Nucleon Interaction and Fermi Liquid Theory

We use the induced interaction of Babu and Brown to derive two novel relations between the quasiparticle interaction in nuclear matter and the unique low momentum nucleon-nucleon interaction V_low k in vacuum. These relations provide two independent constraints on the Fermi liquid parameters of nuclear matter. We derive the full renormalization group equations in the particle-hole channels from the induced interaction. The new constraints, together with the Pauli principle sum rules, define four combinations of Fermi liquid parameters that are invariant under the renormalization group flow. Using empirical values for the spin-independent Fermi liquid parameters, we are able to compute the major spin-dependent ones by imposing the new constraints and the Pauli principle sum rules. The effects of tensor forces are discussed.Comment: 30 pages, 4 figures, uses feynmp.sty (included), minor revisions, to appear in Nucl. Phys.

Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.

The pool of beta cell-specific CD8+ T cells in type 1 diabetes (T1D) sustains an autoreactive potential despite having access to a constant source of antigen. To investigate the long-lived nature of these cells, we established a DNA methylation-based T cell 'multipotency index' and found that beta cell-specific CD8+ T cells retained a stem-like epigenetic multipotency score. Single-cell assay for transposase-accessible chromatin using sequencing confirmed the coexistence of naive and effector-associated epigenetic programs in individual beta cell-specific CD8+ T cells. Assessment of beta cell-specific CD8+ T cell anatomical distribution and the establishment of stem-associated epigenetic programs revealed that self-reactive CD8+ T cells isolated from murine lymphoid tissue retained developmentally plastic phenotypic and epigenetic profiles relative to the same cells isolated from the pancreas. Collectively, these data provide new insight into the longevity of beta cell-specific CD8+ T cell responses and document the use of this methylation-based multipotency index for investigating human and mouse CD8+ T cell differentiation